Amclamed Powder for Oral Suspension

Qualitative and quantitative composition:
Each film coated tablet contains: Amoxicillin Trihydrate USP Eq. to Amoxicillin 500mg and Diluted
Potassium Clavulanate BP Eq. to Clavulanic Acid 125mg
Each 5 ml of reconstituted suspension contains: Amoxicillin Trihydrate BP Eq. to Amoxicillin 200mg
and Diluted Potassium Clavulanate BP Eq. to Clavulanic Acid 28.5mg
Pharmaceutical form: Tablet and Oral powder for suspension
Pharmacology
Pharmacotherapeutics Group: Combination of penicillins including beta-lactamase inhibitors,
ATC Code: J01CR02.
Pharmacodynamic Properties:
Mode of action: Amoxicillin is a semisynthetic penicillin (beta-lactam antibiotic) that inhibits one or
more enzymes (often referred to as penicillin -binding proteins, PBPs) in the biosynthetic pathway of
bacterial peptidoglycan, which is an integral structural component of the bacterial cell wall. Inhibition
of peptidoglycal synthesis leads to weakening of the cell wall, which is usually followed by cell lysis
and death Amoxicillin is susceptible to degradation by beta-lactamases produced by resistant
bacteria and therefore the spectrum of activity of amoxicillin alone does not include organisms which
Indications:
Amoxicillin and Clavulanate Potassium tablets are indicated for the treatment of the following
infections in adults and children
• Lower Respiratory Infections: Caused by β-lactamase-producing strains of H. influenzae and
M. catarrhalis
• Upper Respiratory tract infection e.g., Otitis Media: Caused by β-lactamase-producing strains of H.influenzae and M. catarrhalis.
Sinusitis: Caused by β-lactamase-producing strains of H. influenza and M. catarrhalis
Skin and Skin Structure Infections: Caused byβ-lactamase-producing strains of S. aureus, E. coli
& Klebsiella spp.
Urinary Tract Infections: Caused by β-lactamase-producing strains of E. coli & Klebsiella spp., and Enterobacter spp. Bone and Joint Infection e.g., osteomyelitis